Heating tissues beyond which temperature is commonly associated with pain?

Heating tissues beyond which temperature is commonly associated with pain?

• A. 40-45 degrees Celsius
• B. Less than 40 degrees Celsius
• C. 37 degrees Celsius
• D. Greater than 45 degrees Celsius

Answer: (D)

Heat detected by the body's nociceptors has a higher threshold than ordinary warmth. Warmth up to about 40°C is usually comfortable, but once temperatures rise into the low to mid-40s, pain typically begins as heat-sensitive pain fibers activate. As you push beyond about 45°C, the stimulus is reliably painful and the risk of tissue damage increases because proteins start to denature and cells sustain injury. So heating tissue beyond 45°C is commonly associated with pain.

Heat detected by the body's nociceptors has a higher threshold than ordinary warmth. Warmth up to about 40°C is usually comfortable, but once temperatures rise into the low to mid-40s, pain typically begins as heat-sensitive pain fibers activate. As you push beyond about 45°C, the stimulus is reliably painful and the risk of tissue damage increases because proteins start to denature and cells sustain injury. So heating tissue beyond 45°C is commonly associated with pain.